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Microdose Lupron Flare Protocol for IVF – Sample CalendarIn Vitro Fertilization Microflare Protocol

Microdose Lupron Flare Protocol for IVF – Sample CalendarIn Vitro Fertilization Microflare Protocol

The sample schedule and calendar below is for IVF stimulation using the flare protocol.

  • The flare protocol is used to “jump start” ovarian response to stimulation in poor responders, in women of advanced reproductive age, and in women with low ovarian reserve.
  • As women lose eggs due to aging, it can be hard to stimulate ovaries to produce enough follicles and eggs for a good chance for success with in vitro fertilization.
  • This sample in vitro fertilization cycle shows a microdose Lupron flare plan with timing of drugs, ovarian stimulation monitoring, and IVF procedures.

Flare IVF Protocol Calendar


Sunday Monday Tuesday Wednesday Thursday Friday Saturday
Birth control pill
Birth control pill
Last birth control pill (of about 14 pills)
No meds
No meds
Baseline blood and ultrasound
Start diluted lupron (DL) twice daily
DL twice daily
DL twice daily
Start of stimulation shots
DL twice daily
Stimulation day 2
DL twice daily
Stimulation day 3
DL twice daily
Stimulation day 4
Blood and ultrasound
DL twice daily
Stimulation day 5
DL twice daily
Stimulation day 6
DL twice daily
Stimulation day 3
Blood and ultrasound – follicles now are ready
HCG trigger shot at night
15 16
Egg Retrieval Procedure
Fertilization check in morning
Start progesterone
18 19
Embryo Transfer Procedure
Day 3 transfer of cleavage stage embryos
20 21
Embryo Transfer Procedure
Day 5 transfer of blastocyst stage embryos
22 23 24 25 26 27 28
29 30
Blood pregnancy test

Key to flare IVF calendar:

Blood and ultrasound = blood test for IVF hormone values (estrogen levels in IVF stimulation are important) and transvaginal ultrasound to measure the follicle sizes in the ovaries. These visits usually take about 20-30 minutes in our offices and can be scheduled as early as 6:30AM.

DL = diluted Lupron, a subcutaneous injection of a very low dose of Lupron. This drug is taken twice daily starting on the third pill free day (after the last birth control pill).

Stim = ovarian stimulation. Involves subcutaneous injection of a medication containing follicle stimulating hormone (FSH), which causes multiple follicles containing eggs to develop in the ovaries. Ovarian stimulation with a flare usually lasts about 8-11 days.

HCG injection = subcutaneous or intramuscular injection of a medication called HCG, which causes the eggs to complete the maturation process.

Progesterone = vaginal cream or suppositories or intramuscular injection of a medication (female hormone) called progesterone. This drug helps to prepare a receptive uterine lining for embryo implantation.

Egg retrieval procedure = procedure to get eggs from the ovaries

Embryo transfer procedure = procedure to put embryos in the uterus

The example above is a typical flare stimulation cycle. Most patients will need 3 or 4 visits for monitoring the stimulation (shown as “Blood and Ultrasound” on the calendar) before the HCG trigger shot. It depends on the woman’s response to the ovarian stimulating medications.

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